Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S.
CAS：869898-86-2
分子式：C24H27NO6
分子量：425.5
纯度：98%
存储：Store at -20°C

Background:

Platencin is a natural, broad spectrum Gram-positive antibiotic isolated from S. platensis, which is also the source of platensimycin.¹Platencin inhibits two key enzymes in bacterial fatty acid synthesis, β-ketoacyl-ACP synthases II and III (FabF and FabH, respectively), unlike platensimycin which only targets FabF.¹The IC50 values for platencin against FabF and FabH are 1.95 and 3.91 μg/ml, respectively.¹It does not exhibit cross-resistance to antibiotic resistant bacterial strains, including methicillin-resistant S. aureus, vancomycin-intermediate S. aureus, and vancomycin-resistant Enterococci. For these reasons, platencin has potential applications in fighting antibiotic resistant bacteria.^2,3

参考文献：

1. Wang, J., Kodali, S., Lee, S.H., et al. Discovery of platencin, a dual FabF and FabH inhibitor with in vivo antibiotic properties. Proc. Natl. Acad. Sci. USA 104(18), 7612-7616 (2007).

2. Martens, E., and Demain, A.L. Platensimycin and platencin: Promising antibiotics for future application in human medicine. J. Antibiot. (Tokyo) 64(11), 705-710 (2011).

3. Allahverdiyev, A.M., Bagirova, M., Abamor, E.S., et al. The use of platensimycin and platencin to fight antibiotic resistance. Infect. Drug Resist. 6, 99-114 (2013).