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R-8507
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
R-8507图片
CAS NO:338773-13-0
规格:98%
分子量:348.7
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI).
CAS:338773-13-0
分子式:C16H8ClF3N4
分子量:348.7
纯度:98%
存储:Store at -20°C

Background:

R-8507 is a small molecule antagonist of the TNF-α type 1 receptor (TNF-αRI). It inhibits the expression of intercellular adhesion molecule-1 (ICAM-1) induced by TNF-α and IL-1β with EC50 values of 2.45 and 3.79 µM, respectively, in an ELISA using A549 lung epithelial cells.{|Gururaja2007|} It also disrupts the interaction of the TNF-αRI with receptor interacting protein 1 (RIP1) and TNF-αR-associated death domain protein (TRADD), preventing internalization of the receptor complex.