Streptonigrin(Bruneomycin)是由链霉菌(Streptomycesflocculus)产生的一种天然产物，具有抗肿瘤和抗菌活性。Streptonigrin可作为pan-PAD抑制剂，抑制PAD1，PAD2，PAD3和PAD4的IC50分别为48.3±34.2μM，26.1±0.3μM，0.43±0.03μM和2.5±0.4μM。
CAS：3930-19-6
分子式：C25H22N4O8
分子量：506.46
纯度：98%
存储：Store at -20°C

Background:

Streptonigrin (Bruneomycin), a natural product produced by Streptomyces flocculus, possesses both anti-tumor and anti-bacterial activity. Streptonigrin acts as a pan-PAD inhibitor with IC50s of 48.3±34.2 µM, 26.1±0.3 µM, 0.43±0.03 µM, and 2.5±0.4 µM for PAD1, PAD2, PAD3, and PAD4, respectively[1].

[1]. Dreyton CJ, et al. Insights into the mechanism of Streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15;22(4):1362-9.