PAR-4AgonistPeptide,amideTFA(PAR-4-APTFA;AY-NH2TFA)是一种蛋白酶激活受体-4(PAR-4)激动剂，对PAR-1或PAR-2都没有作用，且其作用会被PAR-4拮抗剂阻断。
CAS：1228078-65-6
分子式：C36H49F3N8O9
分子量：794.82
纯度：98%
存储：Store at -20°C

Background:

PAR-4 Agonist Peptide, amide TFA (PAR-4-AP TFA; AY-NH2 TFA) is a proteinase-activated receptor-4 (PAR-4) agonist, which has no effect on either PAR-1 or PAR-2 and whose effects are blocked by a PAR-4 antagonist[1].

Compared with their BALB/cBy controls, SCID mice have a significantly greater abdominal response to colorectal distension (CRD) at the distension levels of 0.04 to 0.1 mL increasing the intensity of EMG response by 384% to 132%, respectively (P<0.01; P<0.01; P<0.01; P<0.001). PAR-4 activation effectively reverses this hypersensitivity (P<0.01, P<0.05; P<0.05; P<0.05)[1].

[1]. Annaházi A, et al. Proteinase-activated receptor-4 evoked colorectal analgesia in mice: an endogenously activatedfeed-back loop in visceral inflammatory pain. Neurogastroenterol Motil. 2012 Jan;24(1):76-85, e13.