| CAS NO: | 2143061-82-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| Name: AZD-5991 S-enantiomer CAS#: 2143061-82-7 (AZD-5991 S-enantiomer) Chemical Formula: C35H34ClN5O3S2 Exact Mass: 671.1792 Molecular Weight: 672.259 | |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Technical Information | Synonym: AZD-5991; AZD-5991 S-enantiomer; AZD 5991 S-enantiomer. Chemical Name: 16-chloro-11,21,25,61-tetramethyl-11H,21H,61H-10-oxa-4,8-dithia-1(7,3)-indola-2(4,3),6(3,5)-dipyrazola-9(3,1)-naphthalenacyclotridecaphane-12-carboxylic acid InChi Key: KBQCEQAXHPIRTF-UHFFFAOYSA-N InChi Code: InChI=1S/C35H34ClN5O3S2/c1-20-31-29(38-40(20)3)19-45-17-22-15-23(41(4)37-22)18-46-24-14-21-8-5-6-9-25(21)30(16-24)44-13-7-10-26-27-11-12-28(36)32(31)33(27)39(2)34(26)35(42)43/h5-6,8-9,11-12,14-16H,7,10,13,17-19H2,1-4H3,(H,42,43) SMILES Code: CN1C(C(O)=O)=C(CCCOC2=C(C=CC=C3)C3=CC(SC4)=C2)C5=CC=C(Cl)C(C6=C(C)N(C)N=C6CSCC7=NN(C)C4=C7)=C51 |
AZD-5991 S-enantiomer, the S-enantiomer of AZD-5991, is the less active enantiomer of AZD-5991. AZD-5991 S-enantiomer is a Mcl-1 inhibitor with an IC50 of 6.3 μM in FRET assay and a Kd of 0.98 μM in surface plasmon resonance (SPR) assay.
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