Bexagliflozin (formerly known as THR 1442; EGT1442; EGT-1442) is a potent and selective SGLT2 inhibitor with antidaibetic activity. It attenuates blood glucose and HbA(1c) levels in db/db mice and prolongs the survival of stroke-prone rats. The IC(50) values for EGT1442 against human SGLT1 and SGLT2 are 5.6μM and 2nM, respectively. In normal rats and dogs a saturable urinary glucose excretion was produced with an ED(50) of 0.38 and 0.09mg/kg, respectively. EGT1442 showed favorable properties both in vitro and in vivo and could be beneficial to the management of type 2 diabetic patients.

纯度：≥98%

CAS：1118567-05-7