NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 uM).
CAS：141774-20-1
分子式：C25H50N4O2.2HCl
分子量：511.6
纯度：98%
存储：Store at -20°C

Background:

NPC-15437 is a selective protein kinase C (PKC) inhibitor (IC50 = 19 uM). It competitively inhibits phorbol ester- (Ki = 5 uM) and phosphatidylserine-induced (Ki = 12 uM) PKC activity but does not affect the activity of cAMP-dependent or Ca2+/calmodulin-dependent protein kinases. PKC signaling is involved in learning and memory, and when NPC-15437 was administered after Y maze training (0.1-10 mg/kg i.p.), it led to memory retention deficits in mice.