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Intoplicine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Intoplicine图片
CAS NO:125974-72-3
规格:98%
分子量:348.44
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Intoplicine是DNA拓扑异构酶I和II抑制剂。
CAS:125974-72-3
分子式:C21H24N4O
分子量:348.44
纯度:98%
存储:Store at -20°C

Background:

Intoplicine is a DNA topoisomerase I and II inhibitor.


Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. Intoplicine (RP60475) is the most active analogue evaluated in the 7H-benzo[e]-pyrido-[4,3-b]-indole series of antineoplastic compounds. Intoplicine exerts its activity through inhibition of DNA topoisomerase I and II[1]. Intoplicine is found to unwind DNA and to inhibit purified calf thymus topoisomerase II via a stabilization of the ternary cleavable complex[2].



[1]. Eckardt JR, et al. Activity of Intoplicine (RP60475), a new DNA topoisomerase I and II inhibitor, against human tumor colony-forming units in vitro. J Natl Cancer Inst. 1994 Jan 5;86(1):30-3. [2]. Morjani H, et al. Molecular and cellular interactions between Intoplicine, DNA, and topoisomerase II studied by surface-enhanced Raman scattering spectroscopy. Cancer Res. 1993 Oct 15;53(20):4784-90.