MK771 is a therapeutic agent and an analogue of the Thyrotropin Releasing Hormone (TRH). TRH and its analogues may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. References: Hutson PH, Semark JE, Middlemiss DN. The TRH analogue MK-771, increases acetylcholine release in hippocampus but not striatum of the conscious rat. Neurosci Lett. 1990 Aug 14;116(1-2):149-55. PubMed PMID: 2124336. 2: Sills MA, Jacobowitz DM. Chronic administration of desipramine or nialamide decreases wet-dog shakes in rats produced by the TRH-analog MK-771. Brain Res. 1987 Jan 13;401(1):195-9. PubMed PMID: 3101979. 3: Horita A, Carino MA, Lai H. Preliminary studies on the effects of a TRH analog, MK-771, in an animal model of Alzheimer's disease. Proc West Pharmacol Soc. 1987;30:57-8. PubMed PMID: 3114755. 4: Simasko SM, Horita A. Treatment of rats with the TRH analog MK-771. Down-regulation of TRH receptors and behavioral tolerance. Neuropharmacology. 1985 Feb;24(2):157-65. PubMed PMID: 2986033. 5: Nielsen JA, Moore KE. Thyrotropin-releasing hormone and its analog MK-771 increase the cerebroventricular perfusate content of dihydroxyphenylacetic acid. J Neurochem. 1984 Aug;43(2):593-6. PubMed PMID: 6429282. 6: Brady LS, Valentine JO, Barrett JE. Effects of thyrotropin-releasing hormone (TRH) and a TRH analogue, MK-771, on punished responding of squirrel monkeys. Psychopharmacology (Berl). 1984;83(2):151-4. PubMed PMID: 6431464. 7: Barrett JE. Effects of thyrotropin-releasing hormone (TRH) and MK-771 on schedule-controlled behavior of squirrel monkeys, rabbits and pigeons. Peptides. 1983 Mar-Apr;4(2):177-81. PubMed PMID: 6413956. 8: Funatsu K, Teshima S, Inanaga K. Binding of TRH, DN-1417 and MK-771 to TRH receptors in the rat brain. Relationship to their central actions. Kurume Med J. 1983;30 Suppl:S45-50. PubMed PMID: 6090771. 9: Rastogi RB, Singhal RL. MK-771 enhances the turnover of norepinephrine in brain. Res Commun Chem Pathol Pharmacol. 1981 Jul;33(1):187-90. PubMed PMID: 6115460. 10: Horita A, Carino MA. A comparison of the pharmacological properties of TRH and MK-771. Proc West Pharmacol Soc. 1981;24:347-8. PubMed PMID: 6789338. 1 Horita A, Carino MA, Zabawska J, Lai H. TRH analog MK-771 reverses neurochemical and learning deficits in medial septal-lesioned rats. Peptides. 1989 Jan-Feb;10(1):121-4. PubMed PMID: 2501767. 12: Sills MA, Jacobowitz DM. Propranolol and methylatropine antagonize the cardiovascular effects produced by microinjection of the TRH analog MK-771 into the preoptic suprachiasmatic nucleus. Peptides. 1988 Jul-Aug;9(4):893-8. PubMed PMID: 3147455. 13: Sills MA, Mellow AM, Sunderland T, Jacobowitz DM. Central muscarinic cholinergic antagonists block wet-dog shakes produced by the TRH analog MK-771 in the rat. Brain Res. 1988 Jun 21;453(1-2):385-8. PubMed PMID: 3135919. 14: Bhargava HN, Matwyshyn GA. Comparative effects of thyrotropin releasing hormone, MK-771 and DN-1417 on morphine abstinence syndrome. Psychopharmacology (Berl). 1985;87(2):141-6. PubMed PMID: 2996045. 15: Brady LS, Barrett JE. Effects of thyrotropin-releasing hormone (TRH) and MK-771 on behavior of squirrel monkeys controlled by noxious stimuli. Peptides. 1984 Jul-Aug;5(4):783-7. PubMed PMID: 6436798. 16: Yamada K, Demarest KT, Moore KE. Effects of behaviorally active doses of thyrotropin-releasing hormone and its analog MK-771 on dopaminergic neuronal systems in the brain of the rat. Neuropharmacology. 1984 Jul;23(7A):735-9. PubMed PMID: 6433220. 17: Vickers S, Duncan CA, Arison BH, Ramjit HG, Rosegay A, Nutt RF, Veber DF. Metabolism of the TRH analog L-pyro-2-aminoadipyl-L-histidyl-[3H]-L-thiazolidine-4-carboxamide (MK-771) in gut and brain tissue of rats: the implications for its bioavailability. Drug Metab Dispos. 1983 Mar-Apr;11(2):147-51. PubMed PMID: 6133720. 18: Yarbrough GG, Faison EP, Antolik EK. MK-771 antagonizes the enhanced response to apomorphine in rats treated chronically with haloperidol - implications for tardive dyskinesia. Neurosci Lett. 1982 Dec 31;34(3):321-3. PubMed PMID: 6819493. 19: Santori EM, Schmidt DE, Kalivas PW, Horita A. Failure of muscarinic blockade to antagonize analepsis induced by thyrotropin-releasing hormone and MK-771 in the rat. Psychopharmacology (Berl). 1981;74(1):13-6. PubMed PMID: 6115440. 20: Lotti VJ, Yarbrough GG, Clineschmidt BV. Investigations on the interaction of thyrotropin-releasing hormone (TRH) and MK-771 with central noradrenergic mechanisms. Psychopharmacology (Berl). 1980;70(2):145-8. PubMed PMID: 6776573.

纯度：≥98%

CAS：66537-55-1