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AGI-5198(IDH-C35)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AGI-5198(IDH-C35)图片
CAS NO:1355326-35-0
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
AGI5198,AGI 5198, IDHC35
产品介绍

生物活性

AGI-5198 (IDH-C35)是一种非常有效的选择性IDH1突变抑制剂,具有潜在的抗癌活性。

靶点信息

R132H-IDH1R132C-IDH1
70 nM0.16 μM

化学数据

目录号A12902
作用机制Inhibitor (抑制剂)
M. Wt462.56
FormulaC27H31FN4O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1355326-35-0
SynonymsAGI5198,AGI 5198, IDHC35
SMILESCC1=CC=CC=C1C(C(=O)NC2CCCCC2)N(C3=CC(=CC=C3)F)C(=O)CN4C=CN=C4C

溶解度

In vitro (25°C)DMSO22 mg/mL (47.56 mM)
WaterInsoluble
Ethanol13 mg/mL (28.1 mM)
In vivo0.5% methylcellulose+0.2% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.62 mL108.09 mL216.19 mL
0.5 mM4.32 mL21.62 mL43.24 mL
1 mM2.16 mL10.81 mL21.62 mL
5 mM0.43 mL2.16 mL4.32 mL

*The above data is based on the productmolecular weight 462.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.