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Crisaborole(AN2728)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Crisaborole(AN2728)图片
CAS NO:906673-24-3
包装与价格:
包装价格(元)
10mg电议
50mg电议

产品名称
AN 2728, AN-2728
产品介绍

生物活性

AN2728是一种局部给药的含硼抗炎化合物,可抑制PDE4活性,从而抑制TNFalpha,IL-12,IL-23和其他细胞因子的释放。抑制PDE4的 IC50 值为0.49 μM。

化学数据

目录号A12776
作用机制Inhibitor (抑制剂)
M. Wt251.08
FormulaC14H10BNO3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.906673-24-3
SynonymsAN 2728, AN-2728
SMILESB1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O

溶解度

In vitroDMSO47 mg/mL (187.21 mM)
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM39.83 mL199.14 mL398.28 mL
0.5 mM7.97 mL39.83 mL79.66 mL
1 mM3.98 mL19.91 mL39.83 mL
5 mM0.8 mL3.98 mL7.97 mL

*The above data is based on the productmolecular weight 251.08. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.