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LDE225 Diphosphate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LDE225 Diphosphate图片
CAS NO:1218778-77-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品名称
LDE-225, LDE 225
产品介绍

生物活性

LDE225 Diphosphate 是一种具有潜在抗肿瘤活性的口服生物利用小分子平滑(Smo)拮抗剂。抑制Hedgehog (Hh)信号通路,无细胞试验中IC50分别为1.3 nM (小鼠)和2.5 nM(人)。

化学数据

目录号A12774
作用机制Inhibitor (抑制剂)
M. Wt681.49
FormulaC26H32F3N3O11P2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1218778-77-8
SynonymsLDE-225, LDE 225
SMILESC[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F.OP(=O)(O)O.OP(=O)(O)O

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM14.67 mL73.37 mL146.74 mL
0.5 mM2.93 mL14.67 mL29.35 mL
1 mM1.47 mL7.34 mL14.67 mL
5 mM0.29 mL1.47 mL2.93 mL

*The above data is based on the productmolecular weight 681.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.