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NU7026
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NU7026图片
CAS NO:154447-35-5
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品名称
NU 7026, NU-7026
产品介绍

生物活性

NU7026是一种新型的在无细胞试验中IC50为0.23 μM,作用于DNA-PK比作用于PI3K选择性高60倍,对ATM和ATR没有抑制活性。可增强用于治疗白血病的拓扑异构酶II毒物的细胞毒性。

靶点信息

DNA-PK (Cell-free assay)PI3K (Cell-free assay)ATM (Cell-free assay)ATR (Cell-free assay)
0.23 μM13 μM>100 μM>100 μM

化学数据

目录号A12752
作用机制Inhibitor (抑制剂)
M. Wt281.31
FormulaC17H15NO3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.154447-35-5
SynonymsNU 7026, NU-7026
SMILESC1COCCN1C2=CC(=O)C3=C(O2)C4=CC=CC=C4C=C3

溶解度

In vitro (25°C)DMSO1 mg/mL (3.55 mM)
WaterInsoluble
EthanolInsoluble
In vivo1% DMSO+30% polyethylene glycol+1% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM35.55 mL177.74 mL355.48 mL
0.5 mM7.11 mL35.55 mL71.1 mL
1 mM3.55 mL17.77 mL35.55 mL
5 mM0.71 mL3.55 mL7.11 mL

*The above data is based on the productmolecular weight 281.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.