生物活性
PRT2607，也称为PRT062607，P505-15和BIIB057，是一种新型，高度选择性且口服可生物利用的小分子SYK抑制剂（SYK IC（50）= 1 nM），具有至少80倍的抗SYK活性 大于对其他激酶的亲和力。
Targets
| Target | Value |
| Syk | IC50: 1nM |
| FGR | IC50: 81nM |
| MLK1 | IC50: 88nM |
| YES | IC50: 123nM |
| FLT3 | IC50: 139nM |
| PAK5 | IC50: 166nM |
| Lyn | IC50: 192nM |
| c-Src | IC50: 244nM |
| LCK | IC50: 249nM |
化学数据
| 目录号 | A12731 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 429.91 |
| Formula | C19H24ClN9O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1370261-97-4 |
| Synonyms | P505-15, PRT2607, PRT-2607, PRT 2607, PRT-062607, PRT 062607, P505-15, BIIB057 |
| SMILES | C1CC[C@H]([C@H](C1)N)NC2=NC=C(C(=N2)NC3=CC=CC(=C3)N4N=CC=N4)C(=O)N.Cl |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 23.26 mL | 116.3 mL | 232.61 mL |
| 0.5 mM | 4.65 mL | 23.26 mL | 46.52 mL |
| 1 mM | 2.33 mL | 11.63 mL | 23.26 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.65 mL |
*The above data is based on the productmolecular weight 429.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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