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PP1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PP1图片
CAS NO:172889-26-8
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品名称
PP-1, PP 1
产品介绍

生物活性

PP1是Src家族酪氨酸激酶的有效抑制剂。抑制p56lck和p59fynT(IC50值分别为5和6 nM)。在ZAP-70和JAK2上显示的选择性> 8000倍。还适度抑制p38,CSK,PDGF受体,RET衍生的癌蛋白,c-Kit和Bcr-Abl。

Targets

TargetValue
LCKIC50: 5nM
FynIC50: 6nM
KitIC50: ~75nM
EGFRIC50: 250nM
Bcr-AblIC50: 1μM
JAK2IC50: >50μM
ZAP70IC50: >100μM

化学数据

目录号A12724
作用机制Inhibitor (抑制剂)
M. Wt281.36
FormulaC16H19N5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.172889-26-8
SynonymsPP-1, PP 1
SMILESCC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C

溶解度

In vitroDMSO4 mg/mL (14.21 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM35.54 mL177.71 mL355.42 mL
0.5 mM7.11 mL35.54 mL71.08 mL
1 mM3.55 mL17.77 mL35.54 mL
5 mM0.71 mL3.55 mL7.11 mL

*The above data is based on the productmolecular weight 281.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.