ML-077, formerly known as VU0255011, is a highly selective, potent, saline soluble, "best in class" KCC2 antagonist for high fidelity in vitro studies on KCC2 function with IC(50)=537 nM. ML-077 is cell permeable and exhibits submicromolar potency, and shows greater than 10-fold selectivity over other closely related NKCC transporters. References: Olde Engberink AHO, Meijer JH, Michel S. Chloride cotransporter KCC2 is essential for GABAergic inhibition in the SCN. Neuropharmacology. 2018 Aug;138:80-86. doi: 10.1016/j.neuropharm.2018.05.023. Epub 2018 May 18. PubMed PMID: 29782876.

纯度：≥98%

CAS：1135304-61-8