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JNJ-28312141
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
JNJ-28312141图片
CAS NO:885692-52-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品名称
JNJ 28312141, JNJ28312141
产品介绍

生物活性

JNJ-28312141是一种口服活性CSF1R抑制剂(Colony-stimulating factor-1受体,CRF1R),也是一种FLT3抑制剂。CSF1R在许多肿瘤中表达,是巨噬细胞的生长因子并介导破骨细胞分化。JNJ-28312141代表一种在急性髓样白血病中以及在依赖CSF-1的巨噬细胞和破骨细胞有助于肿瘤生长和骨骼事件的环境中具有潜在治疗活性的新药物。

化学数据

目录号A12687
作用机制Inhibitor (抑制剂)
M. Wt460.57
FormulaC26H32N6O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.885692-52-4
SynonymsJNJ 28312141, JNJ28312141
SMILESCN(C)CC(=O)N1CCC(CC1)C2=CC(=C(C=C2)NC(=O)C3=NC=C(N3)C#N)C4=CCCCC4

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.71 mL108.56 mL217.12 mL
0.5 mM4.34 mL21.71 mL43.42 mL
1 mM2.17 mL10.86 mL21.71 mL
5 mM0.43 mL2.17 mL4.34 mL

*The above data is based on the productmolecular weight 460.57. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.