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Sorafenib
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Sorafenib图片
CAS NO:284461-73-0
规格:98%
分子量:464.82
包装与价格:
包装价格(元)
20mg电议
50mg电议
200mg电议

产品介绍
Raf kinases and tyrosine kinases inhibitor
CAS:284461-73-0
分子式:C21H16ClF3N4O3
分子量:464.82
纯度:98%
存储:Store at -20°C

Background:

Sorafenib is an oral multikinase inhibitor with activity against Raf kinase and several receptor tyrosine kinases, including vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor (PDGFR), FLT3, Ret, and c-Kit. sorafenib, inhibits tumor growth and disrupts tumor microvasculature through antiproliferative, antiangiogenic, and/or proapoptotic effects. sorafenib blocks Raf kinase signaling, inhibits tumor cell proliferation, and induces apoptosisin vitro. In addition, sorafenib exhibits robust antitumor efficacy.


参考文献


1. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinoma model PLC/PRF/5. L Liu, Y Cao, C Chen, X Zhang, A McNabola, D Wilkie? Cancer research, 2006


2. Phase II study of?sorafenib?in patients with advanced hepatocellular carcinoma. GK Abou-Alfa, L Schwartz, S Ricci. Journal of clinical Oncology. 2006