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GSK481
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK481图片
CAS NO:1622849-58-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
GSK 481, GSK-481
产品介绍

生物活性

GSK481是新型的RIP1抑制剂苯并a庚酮(BOAz)系列。受体相互作用蛋白激酶1(RIP1)已被认为是通过调节程序性坏死调节炎症的关键因素。已显示对该激酶的抑制作用可阻止细胞坏死,从而将RIP1确定为潜在治疗多种炎性疾病的可行靶标。

靶点信息

RIP1

化学数据

目录号A12615
作用机制Inhibitor (抑制剂)
M. Wt377.39
FormulaC21H19N3O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1622849-58-4
SynonymsGSK 481, GSK-481
SMILESO=C(C1=NOC(CC2=CC=CC=C2)=C1)N[C@H]3COC4=CC=CC=C4N(C)C3=O

溶解度

In vitroDMSO70 mg/mL (185.48 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM26.5 mL132.49 mL264.98 mL
0.5 mM5.3 mL26.5 mL53 mL
1 mM2.65 mL13.25 mL26.5 mL
5 mM0.53 mL2.65 mL5.3 mL

*The above data is based on the productmolecular weight 377.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.