ML350 , formerly known as CYM-50202, is an antagonist of KOR (IC50 = 12.6 nM) with good and moderate selectivity against the DOR and MOR. CYM-50202 displayed high solubility, an encouraging pharmacokinetic (PK) profile in rat, and excellent CNS penetration. Perhaps more importantly, CYM-50202 did not display long lasting pharmacodynamic effects observed with prototypical KOR antagonists. References: Guerrero M, Urbano M, Brown SJ, Cayanan C, Ferguson J, Cameron M, Devi LA, Roberts E, Rosen H. Optimization and characterization of an opioid kappa receptor (OPRK1) antagonist. 2013 Apr 15 [updated 2014 Sep 18]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available from .gov/books/NBK179827/ PubMed PMID: 24479196.

纯度：≥98%

CAS：1565852-90-5