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(S)-10-Hydroxycamptothecin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(S)-10-Hydroxycamptothecin图片
CAS NO:19685-09-7
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
10mM * 1mL in DMSO电议

产品名称
HCPT;SN38;Ampule;NSC 107124;HYDROCAMPTOTHECINE;HYDROXYCAMPTOTHECIN;
产品介绍

生物活性

(S)-10-Hydroxycamptothecin是喜树碱衍生物,它通过在染色体DNA中产生链断裂并诱导细胞凋亡来抑制DNA拓扑异构酶。

靶点信息

DNA topoisomerase I

化学数据

目录号A11997
作用机制Inhibitor (抑制剂)
M. Wt364.35
FormulaC20H16N2O5
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.19685-09-7
SynonymsHCPT;SN38;Ampule;NSC 107124;HYDROCAMPTOTHECINE;HYDROXYCAMPTOTHECIN;
SMILESCC[C@@]1(C2=C(COC1=O)C(=O)N3CC4=C(C3=C2)N=C5C=CC(=CC5=C4)O)O

溶解度

In vitro (25°C)DMSOWarmed: 7 mg/mL (19.21 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM27.45 mL137.23 mL274.46 mL
0.5 mM5.49 mL27.45 mL54.89 mL
1 mM2.74 mL13.72 mL27.45 mL
5 mM0.55 mL2.74 mL5.49 mL

*The above data is based on the productmolecular weight 364.35. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.