生物活性
ACY-1215 (Rocilinostat)是一种选择性HDAC6抑制剂，从而通过Hsp90的超乙酰化作用破坏Hsp90蛋白伴侣系统，并防止随后的总蛋白降解。
Targets
| Target | Value |
| HDAC6 | IC50: 4.7nM |
| HDAC2 | IC50: 48nM |
| HDAC3 | IC50: 51nM |
| HDAC1 | IC50: 58nM |
| HDAC8 | IC50: 100nM |
| HDAC7 | IC50: 1.4μM |
| HDAC5 | IC50: 5μM |
| HDAC4 | IC50: 7μM |
| HDAC9 | IC50: >10μM |
| HDAC11 | IC50: >10μM |
| Sirtuin1 | IC50: >10μM |
| Sirtuin2 | IC50: >10μM |
化学数据
| 目录号 | A11940 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 433.5 |
| Formula | C24H27N5O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 1316214-52-4 |
| Synonyms | ACY1215 |
| SMILES | C1=CC=C(C=C1)N(C2=CC=CC=C2)C3=NC=C(C=N3)C(=O)NCCCCCCC(=O)NO |
溶解度
| In vitro (25°C) | DMSO | 73 mg/mL (168.39 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 2% DMSO+30% PEG 300+ddH2O | 4 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 23.07 mL | 115.34 mL | 230.68 mL |
| 0.5 mM | 4.61 mL | 23.07 mL | 46.14 mL |
| 1 mM | 2.31 mL | 11.53 mL | 23.07 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.61 mL |
*The above data is based on the productmolecular weight 433.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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