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GSK 3008348 hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
GSK 3008348 hydrochloride图片
CAS NO:1629249-40-6
规格:98%
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
GSK3008348(hydrochloride)是一种小分子整联蛋白αvβ6拮抗剂,在荧光偏振检测中对人a6蛋白亲和力(pIC50)为8.1,在细胞粘连检测中,其亲合性分别为:ανβ6(pIC50=8.4);ανβ3(pIC50=6);ανβ5(pIC50=6.9);ανβ8(pIC50=7.7)。
CAS:1629249-40-6
分子式:C29H37N5O2.xHCl
分子量:
纯度:98%
存储:Store at -20°C

Background:

GSK 3008348 (hydrochloride) is a small molecule integrin αvβ6 antagonist, extracted from patent WO/2014154725A1, example 1. The affinity (pIC50) for the human - a 6 protein in the Fluorescence Polarisation Assay for GSK 3008348 (hydrochloride) is 8.1, whereas its affinity in the cell Adhesion Assays was for: ανβ6 (pIC50 = 8.4); ανβ3 (pIC50 = 6); ανβ5 (pIC50 = 6.9); ανβ8 (pIC50 = 7.7).




[1]. Anderson Niall Andrew, et al. Preparation of naphthyridine derivatives useful as αvβ6 integrin antagonists. From PCT Int. Appl. (2014), WO 2014154725 A1 20141002.