生物活性
Aminopterin是一种抗肿瘤药。它通过竞争二氢叶酸还原酶的叶酸结合位点而充当酶抑制剂。
化学数据
| 目录号 | A11787 |
| M. Wt | 404.4 |
| Formula | C19H20N8O5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 54-62-6 |
| Synonyms | 4-aminopteroic acid |
| SMILES | C1=CC(=CC=C1C(=O)N[C@@H](CCC(=O)O)C(=O)O)NCC2=CN=C3C(=N2)C(=NC(=N3)N)N |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 24.73 mL | 123.64 mL | 247.28 mL |
| 0.5 mM | 4.95 mL | 24.73 mL | 49.46 mL |
| 1 mM | 2.47 mL | 12.36 mL | 24.73 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.95 mL |
*The above data is based on the productmolecular weight 404.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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