您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Antimycin A3
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Antimycin A3
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Antimycin A3图片
CAS NO:522-70-3
规格:98%
分子量:520.6
包装与价格:
包装价格(元)
1mg电议
5mg电议

产品介绍
Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4.
CAS:522-70-3
分子式:C26H36N2O9
分子量:520.6
纯度:98%
存储:Store at -20°C

Background:

Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4 . Antimycin A3 binds to the Q(inner) site of mitochondrial complex III (cytochrome bc1) and inhibits mitochondrial respiration (IC50 = 38 nM in isolated rat liver mitochondria). It also inhibits ATP-citrate lyase with a Ki value of 60.1 µM, and it stimulates the production of reactive oxygen species. In molecular modeling studies, antimycin binds to a mutant form of Bcl-2 (hBcl-2δ22) and has a Kd value of 0.82 µM for binding to a recombinant mutant form of Bcl-2 (rhBcl-2δ22) in an isothermal calorimetry assay.