Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4.
CAS：522-70-3
分子式：C26H36N2O9
分子量：520.6
纯度：98%
存储：Store at -20°C

Background:

Antimycin A3 is a component of the antimycin A antibiotic complex that is more polar than antimycin A1 and antimycin A2 but not antimycin A4 . Antimycin A3 binds to the Q(inner) site of mitochondrial complex III (cytochrome bc1) and inhibits mitochondrial respiration (IC50 = 38 nM in isolated rat liver mitochondria). It also inhibits ATP-citrate lyase with a Ki value of 60.1 µM, and it stimulates the production of reactive oxygen species. In molecular modeling studies, antimycin binds to a mutant form of Bcl-2 (hBcl-2δ22) and has a Kd value of 0.82 µM for binding to a recombinant mutant form of Bcl-2 (rhBcl-2δ22) in an isothermal calorimetry assay.