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MM-206
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MM-206图片
CAS NO:1809581-87-0
规格:98%
分子量:497.5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
MM-206 is an inhibitor of STAT3 (IC50 = 1.16 μM in an SPR-based competitive assay).
CAS:1809581-87-0
分子式:C22H12F5NO3S2
分子量:497.5
纯度:98%
存储:Store at -20°C

Background:

MM-206 is an inhibitor of STAT3 (IC50 = 1.16 µM in an SPR-based competitive assay). It inhibits STAT3 phosphorylation induced by granulocyte colony-stimulating factor (G-CSF) in HL-60, Kasumi-1, and MOLM-13 acute myeloid leukemia (AML) cells (IC50s = 0.8, 1.9, and 1.1 µM, respectively). MM-206 induces apoptosis more potently in AML cell lines and patient-derived primary AML tumor cells than in acute lymphoblastic leukemia cells, which do not have upregulated STAT3 activity. It also slows disease progression and improves survival in an AML mouse xenograft model when administered at a dose of 30 mg/kg per day.