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Parsaclisib(INCB050465)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Parsaclisib(INCB050465)图片
CAS NO:1426698-88-5
规格:98%
分子量:432.88
包装与价格:
包装价格(元)
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产品介绍
Parsaclisib是一种有效的,选择性的PI3Kδ抑制剂,在1mMATP条件下,IC50值为1nM,对其选择性是对PI3Kα,PI3Kβ,PI3Kγ及其他57种激酶的约20000倍。
CAS:1426698-88-5
分子式:C20H22ClFN6O2
分子量:432.88
纯度:98%
存储:Store at -20°C

Background:

Parsaclisib is a potent and selective PI3Kδ inhibitor, with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases.


Parsaclisib (INCB050465) is a potent and selective PI3Kδ with an IC50 of 1 nM at 1 mM ATP, and shows appr 20,000-fold selectivity for PI3Kα, PI3Kβ, PI3Kγ and 57 other kinases. Parsaclisib displays significant activity with IC50 values ranging from 0.2 to 2 nM in B and T cell proliferation aaasys. Parsaclisib inhibits proliferation of several DLBCL and MCL cell lines in vitro (EC50< 10 nM)[1].



[1]. Niu Shin, et al. Abstract 2671: INCB050465, a novel PI3Kδ inhibitor, synergizes with PIM protein kinase inhibition to cause tumor regression in a model of DLBCL. Cancer Research. 2015, Aug. 75(15).