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Torin 1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Torin 1图片
CAS NO:1222998-36-8
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品名称
Torin1
产品介绍

生物活性

Torin1是mTOR的有效抑制剂,IC50为2-10 nM。

Targets

TargetValue
mTORC1IC50: 2nM
mTORIC50: 4.32nM
DNA-PKIC50: 6.34nM
mTORC2IC50: 10nM
p110γIC50: 171nM
C2αIC50: 176nM
p110α/p85αIC50: 250nM
hVPS34IC50: 533nM
C2βIC50: 549nM
p110δ/p85αIC50: 564nM
PI4KβIC50: 6680nM
PI4KαIC50: >10μM

化学数据

目录号A11587
作用机制Inhibitor (抑制剂)
M. Wt607.62
FormulaC35H28F3N5O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1222998-36-8
SynonymsTorin1
SMILESCCC(=O)N1CCN(CC1)C2=C(C=C(C=C2)N3C(=O)C=CC4=CN=C5C=CC(=CC5=C43)C6=CC7=CC=CC=C7N=C6)C(F)(F)F

溶解度

In vitroDMSO2 mg/mL (3.29 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM16.46 mL82.29 mL164.58 mL
0.5 mM3.29 mL16.46 mL32.92 mL
1 mM1.65 mL8.23 mL16.46 mL
5 mM0.33 mL1.65 mL3.29 mL

*The above data is based on the productmolecular weight 607.62. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.