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TPCA-1
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
TPCA-1图片
CAS NO:507475-17-4
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
TPCA1
产品介绍

生物活性

TPCA-1是一种有效且选择性的人IκB激酶2(IKK-2)抑制剂,IKK-2的IC50 = 17.9 nM,而IKK-1的IC50为400nM。

靶点信息

IKK2 (Cell-free assay)
17.9 nM

化学数据

目录号A11579
作用机制Inhibitor (抑制剂)
M. Wt279.29
FormulaC12H10FN3O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.507475-17-4
SynonymsTPCA1
SMILESC1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F

溶解度

In vitro (25°C)DMSO49 mg/mL (175.44 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% Cremophor EL, 2% N,N-dimethylacetamide14 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM35.81 mL179.03 mL358.05 mL
0.5 mM7.16 mL35.81 mL71.61 mL
1 mM3.58 mL17.9 mL35.81 mL
5 mM0.72 mL3.58 mL7.16 mL

*The above data is based on the productmolecular weight 279.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.