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SB-408124
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
SB-408124图片
CAS NO:288150-92-5
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
SB408124, SB 408124
产品介绍

生物活性

SB-408124是一种选择性的非肽orexin OX1受体拮抗剂(人OX1和OX2受体的Kb值分别为21.7和1405 nM)。体内口服后阻断orexin-A诱导的修饰。

靶点信息

OX1 (membrane)OX1 (whole cell)
27 nM(Ki)57 nM(Ki)

化学数据

目录号A11567
作用机制Antagonist (拮抗剂)
M. Wt356.37
FormulaC19H18F2N4O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.288150-92-5
SynonymsSB408124, SB 408124
SMILESCC1=NC2=C(C=C(C=C2C(=C1)NC(=O)NC3=CC=C(C=C3)N(C)C)F)F

溶解度

In vitro (25°C)DMSO35 mg/mL (98.2 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% propylene glycol, 5% Tween 80, 65% D5W28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM28.06 mL140.3 mL280.61 mL
0.5 mM5.61 mL28.06 mL56.12 mL
1 mM2.81 mL14.03 mL28.06 mL
5 mM0.56 mL2.81 mL5.61 mL

*The above data is based on the productmolecular weight 356.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.