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Rilpivirine(R 278474,TMC 278)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Rilpivirine(R 278474,TMC 278)图片
CAS NO:500287-72-9
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
R278474, TMC278, TMC-278
产品介绍

生物活性

Rilpivirine (R 278474,TMC 278)是第二代非核苷逆转录酶抑制剂(NNRTI),与较老的NNRTIs(例如依非韦伦)相比,具有更高的效力,更长的半衰期和更低的副作用。

化学数据

目录号A11542
作用机制Inhibitor (抑制剂)
M. Wt366.4
FormulaC22H18N6
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.500287-72-9
SynonymsR278474, TMC278, TMC-278
SMILESCC1=CC(=CC(=C1NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C)/C=C/C#N

溶解度

In vitroDMSO66 mg/mL (180.12 mM)
WaterInsoluble
EthanolInsoluble
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM27.29 mL136.46 mL272.93 mL
0.5 mM5.46 mL27.29 mL54.59 mL
1 mM2.73 mL13.65 mL27.29 mL
5 mM0.55 mL2.73 mL5.46 mL

*The above data is based on the productmolecular weight 366.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.