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PF 477736
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
PF 477736图片
CAS NO:952021-60-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品名称
PF-0044736, PF0044736
产品介绍

生物活性

PF 477736是选择性检查点激酶1 (Chk1)抑制剂(Chk1和Chk2的ki值分别为0.49和47 nM)。

靶点信息

Chk1 (Cell-free assay)VEGFR2 (Cell-free assay)Fms (Cell-free assay)YES (Cell-free assay)Chk2 (Cell-free assay)
0.49 nM(Ki)8 nM(Ki)10 nM(Ki)14 nM(Ki)47 nM(Ki)

化学数据

目录号A11520
作用机制Inhibitor (抑制剂)
M. Wt419.48
FormulaC22H25N7O2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.952021-60-2
SynonymsPF-0044736, PF0044736
SMILESCN1C=C(C=N1)C2=NC3=C4C2=CNNC(=O)C4=CC(=C3)NC(=O)[C@@H](C5CCCCC5)N

溶解度

In vitro (25°C)DMSO5 mg/mL (11.92 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+40% PEG 3004 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM23.84 mL119.2 mL238.39 mL
0.5 mM4.77 mL23.84 mL47.68 mL
1 mM2.38 mL11.92 mL23.84 mL
5 mM0.48 mL2.38 mL4.77 mL

*The above data is based on the productmolecular weight 419.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.