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NVP-TAE 226
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NVP-TAE 226图片
CAS NO:761437-28-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
TAE226, TAE 226
产品介绍

生物活性

NVP-TAE 226是一种强效FAK抑制剂,IC50为5.5 nM,对pyk2(IC50=3.5 nM)有适度的强效作用;对InsR, IGF-1R, ALK和c-Met的效力降低10-100倍。

Targets

TargetValue
PYK2IC50: 3.5nM
FAKIC50: 5.5nM
Insulin ReceptorIC50: 43.5nM
IGF-1RIC50: 140nM
c-MetIC50: 160nM
FLT4IC50: 220nM
KDRIC50: 360nM
FLT3IC50: 480nM
CDK1/CyclinBIC50: 540nM
TekIC50: 580nM
FGFR3(K650E)IC50: 630nM
FGFR1IC50: 750nM
JAK2IC50: 840nM
c-SrcIC50: 905nM
HER2IC50: 945nM
RETIC50: 1.3μM
HER1IC50: 1.7μM
RET(M918T)IC50: 2.3μM
PDK-1IC50: 2.4μM
PDGFRβIC50: 2.6μM
FLT1IC50: 3.4μM
c-AblIC50: 5.85μM
ZAP70IC50: 7.7μM
SykIC50: 7.9μM
PKAIC50: >10μM
PKBIC50: >10μM
C-RafIC50: >10μM

化学数据

目录号A11507
作用机制Inhibitor (抑制剂)
M. Wt468.94
FormulaC23H25ClN6O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.761437-28-9
SynonymsTAE226, TAE 226
SMILESCNC(=O)C1=CC=CC=C1NC2=NC(=NC=C2Cl)NC3=C(C=C(C=C3)N4CCOCC4)OC

溶解度

In vitro (25°C)DMSO93 mg/mL (198.32 mM)
WaterInsoluble
EthanolInsoluble
In vivo0.5% methylcellulose28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.32 mL106.62 mL213.25 mL
0.5 mM4.26 mL21.32 mL42.65 mL
1 mM2.13 mL10.66 mL21.32 mL
5 mM0.43 mL2.13 mL4.26 mL

*The above data is based on the productmolecular weight 468.94. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.