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Nutlin 3a
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nutlin 3a图片
CAS NO:675576-98-4
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
Nutlin-3a, (-)-Nutlin-3
产品介绍

生物活性

Nutlin 3a是与p53结合的MDM2(小鼠双分钟2)有效抑制剂,可诱导p53调控基因的表达,并在表达功能性p53的细胞中表现出有效的抗增殖活性。

靶点信息

p53/MDM2 interaction (Cell-free assay)
90 nM

化学数据

目录号A11501
作用机制Inhibitor (抑制剂)
M. Wt581.49
FormulaC30H30Cl2N4O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.675576-98-4
SynonymsNutlin-3a, (-)-Nutlin-3
SMILESCC(C)OC1=C(C=CC(=C1)OC)C2=N[C@H]([C@H](N2C(=O)N3CCNC(=O)C3)C4=CC=C(C=C4)Cl)C5=CC=C(C=C5)Cl

溶解度

In vitro (25°C)DMSO98 mg/mL (168.53 mM)
WaterInsoluble
Ethanol98 mg/mL
In vivo5% DMSO+55% PEG 300+ddH2O7 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM17.2 mL85.99 mL171.97 mL
0.5 mM3.44 mL17.2 mL34.39 mL
1 mM1.72 mL8.6 mL17.2 mL
5 mM0.34 mL1.72 mL3.44 mL

*The above data is based on the productmolecular weight 581.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.