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Dovitinib(TKI-258)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dovitinib(TKI-258)图片
CAS NO:405169-16-6
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
CHIR-258, CHIR258, TKI258
产品介绍

生物活性

Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂,可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞,IC50值分别为150 nM和90 nM。

Targets

TargetValue
FLT3IC50: 1nM
c-KitIC50: 2nM
FGFR1IC50: 8nM
VEGFR3/FLT4IC50: 8nM
FGFR3IC50: 9nM
VEGFR1/FLT1IC50: 10nM
VEGFR2/Flk1IC50: 13nM
PDGFRβIC50: 27nM
CSF-1R/c-FmsIC50: 36nM
PDGFRαIC50: 210nM
Insulin ReceptorIC50: 2μM
EGFRIC50: 2μM
c-MetIC50: >3μM
EphA2IC50: 4μM
Tie-2IC50: 4μM
IGF-1RIC50: >10μM
HER2IC50: >10μM

化学数据

目录号A11411
作用机制Inhibitor (抑制剂)
M. Wt392.4
FormulaC21H21FN6O
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.405169-16-6
SynonymsCHIR-258, CHIR258, TKI258
SMILESCN1CCN(CC1)C2=CC3=C(C=C2)N/C(=C\4/C(=C5C(=NC4=O)C=CC=C5F)N)/N3

溶解度

In vitro (25°C)DMSO28 mg/mL (71.34 mM)
WaterInsoluble
EthanolInsoluble
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM25.48 mL127.42 mL254.84 mL
0.5 mM5.1 mL25.48 mL50.97 mL
1 mM2.55 mL12.74 mL25.48 mL
5 mM0.51 mL2.55 mL5.1 mL

*The above data is based on the productmolecular weight 392.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.