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MK-5108(VX-689)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MK-5108(VX-689)图片
CAS NO:1010085-13-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
MK5108, VX689
产品介绍

生物活性

MK-5108,也称为VX-689,是Aurora A激酶ATP结合位点的竞争性抑制剂。

靶点信息

Aurora A (Cell-free assay)
0.064 nM

化学数据

目录号A11410
作用机制Inhibitor (抑制剂)
M. Wt461.9
FormulaC22H21ClFN3O3S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1010085-13-8
SynonymsMK5108, VX689
SMILESC1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O

溶解度

In vitro (25°C)DMSO81 mg/mL (175.35 mM)
WaterInsoluble
EthanolInsoluble
In vivo0.5% methylcellulose+0.2% Tween 8028 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.65 mL108.25 mL216.5 mL
0.5 mM4.33 mL21.65 mL43.3 mL
1 mM2.16 mL10.82 mL21.65 mL
5 mM0.43 mL2.16 mL4.33 mL

*The above data is based on the productmolecular weight 461.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.