您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > Apatinib(YN968D1)
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Apatinib(YN968D1)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Apatinib(YN968D1)图片
CAS NO:811803-05-1
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品介绍

生物活性

Apatinib (YN968D1)是一种酪氨酸激酶抑制剂,可选择性抑制血管内皮生长因子受体2(VEGFR2,也称为KDR),后者可抑制VEGF介导的内皮细胞迁移和增殖,从而阻止肿瘤组织中新血管的形成。

Targets

TargetValue
VEGFR2IC50: 1nM
RETIC50: 13nM
c-KitIC50: 429nM
c-SrcIC50: 530nM
PDGFRαIC50: >1μM
EGFRIC50: >10μM
HER2IC50: >10μM
FGFR1IC50: >10μM

化学数据

目录号A11407
作用机制Inhibitor (抑制剂)
M. Wt493.6
FormulaC25H27N5O4S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.811803-05-1
SMILESCS(=O)(=O)O.C1CCC(C1)(C#N)C2=CC=C(C=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4

溶解度

In vitroDMSO77 mg/mL (193.72 mM)
WaterInsoluble
Ethanol10 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.26 mL101.3 mL202.59 mL
0.5 mM4.05 mL20.26 mL40.52 mL
1 mM2.03 mL10.13 mL20.26 mL
5 mM0.41 mL2.03 mL4.05 mL

*The above data is based on the productmolecular weight 493.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.