生物活性
AG-1024 (Tyrphostin)是胰岛素样生长因子-1 (IGF-1) 和胰岛素受体酪氨酸激酶活性的特异性抑制剂。与胰岛素受体相比，IGF-1的IC50值更低。还抑制胰岛素刺激的细胞增殖。
靶点信息
| IGF-1R | Insulin Receptor | | | |
| 7 μM | 57 μM | | | |
化学数据
| 目录号 | A11400 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 305.2 |
| Formula | C14H13BrN2O |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 65678-07-1 |
| Synonyms | AG1024 |
| SMILES | CC(C)(C)C1=C(C(=CC(=C1)C=C(C#N)C#N)Br)O |
溶解度
| In vitro (25°C) | DMSO | 59 mg/mL (193.33 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 1% DMSO+30% polyethylene glycol+1% Tween 80 | 28 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 32.77 mL | 163.83 mL | 327.65 mL |
| 0.5 mM | 6.55 mL | 32.77 mL | 65.53 mL |
| 1 mM | 3.28 mL | 16.38 mL | 32.77 mL |
| 5 mM | 0.66 mL | 3.28 mL | 6.55 mL |
*The above data is based on the productmolecular weight 305.2 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
m.cnreagent.com