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Dabrafenib(GSK2118436A)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dabrafenib(GSK2118436A)图片
CAS NO:1195765-45-7
包装与价格:
包装价格(元)
5mg电议
25mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
GSK2118436A
产品介绍

生物活性

Dabrafenib (GSK2118436A)是一种有效且选择性的B-RAF蛋白激酶抑制剂,具有V600E突变,目前正在临床试验中。

靶点信息

B-Raf (V600E) (Cell-free assay)B-Raf (Cell-free assay)C-Raf (Cell-free assay)
0.8 nM3.2 nM5.0 nM

化学数据

目录号A11381
作用机制Inhibitor (抑制剂)
M. Wt519.6
FormulaC23H20F3N5O2S2
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1195765-45-7
SynonymsGSK2118436A
SMILESCC(C)(C)C1=NC(=C(S1)C2=NC(=NC=C2)N)C3=C(C(=CC=C3)NS(=O)(=O)C4=C(C=CC=C4F)F)F

溶解度

In vitro (25°C)DMSO28 mg/mL (53.89 mM)
WaterInsoluble
EthanolInsoluble
In vivo2% DMSO+45% PEG 300+2% Tween 80+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM19.25 mL96.23 mL192.46 mL
0.5 mM3.85 mL19.25 mL38.49 mL
1 mM1.92 mL9.62 mL19.25 mL
5 mM0.38 mL1.92 mL3.85 mL

*The above data is based on the productmolecular weight 519.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.