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CZC24832
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CZC24832图片
CAS NO:1159824-67-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品名称
CZC 24832, CZC-24832
产品介绍

生物活性

CZC24832是一种有效的选择性PI3Kγ抑制剂(在PI3Kγ依赖性fMLP诱导的中性粒细胞迁移试验中IC50 = 1.0 μM)。

靶点信息

PI3KγPI3KβPI3Kδ
27 nM1.1 μM8.2 μM

化学数据

目录号A11363
作用机制Inhibitor (抑制剂)
M. Wt364.4
FormulaC15H17FN6O2S
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1159824-67-5
SynonymsCZC 24832, CZC-24832
SMILESCC(C)(C)NS(=O)(=O)C1=CN=CC(=C1)C2=CN3C(=NC(=N3)N)C(=C2)F

溶解度

In vitro (25°C)DMSOWarmed: 5 mg/mL (13.72 mM)
WaterInsoluble
EthanolInsoluble
In vivo0.5% CMC28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM27.44 mL137.21 mL274.42 mL
0.5 mM5.49 mL27.44 mL54.88 mL
1 mM2.74 mL13.72 mL27.44 mL
5 mM0.55 mL2.74 mL5.49 mL

*The above data is based on the productmolecular weight 364.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.