生物活性
BIBX 1382是一种细胞可渗透的嘧啶嘧啶化合物，可作为一种有效的，可逆的，ATP竞争性高选择性的EGFR抑制剂。
化学数据
| 目录号 | A11334 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 460.8 |
| Formula | C18H19ClFN7.2HCl |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 196612-93-8 |
| Synonyms | BIBX1382, BIBX-1382 |
| SMILES | CN1CCC(CC1)NC2=NC=C3C(=N2)C(=NC=N3)NC4=CC(=C(C=C4)F)Cl |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 21.7 mL | 108.51 mL | 217.01 mL |
| 0.5 mM | 4.34 mL | 21.7 mL | 43.4 mL |
| 1 mM | 2.17 mL | 10.85 mL | 21.7 mL |
| 5 mM | 0.43 mL | 2.17 mL | 4.34 mL |
*The above data is based on the productmolecular weight 460.8 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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