Platensimycin (PTM) is an antibiotic produced by S.
CAS：835876-32-9
分子式：C24H27NO7
分子量：441.5
纯度：98%
存储：Store at -20°C

Background:

Platensimycin (PTM) is an antibiotic produced by S. platensis that inhibits Gram-positve bacteria by selectively inhibiting cellular lipid biosynthesis (IC50 = 0.1 μM).¹It targets the β-ketoacyl-acyl-carrier-protein synthase I/II, FabF/B, an enzyme that participates in the biosynthesis of fatty acids (IC50s = 48 and 160 nM for S. aureus and E. coli enzymes, respectively).¹By specifically targeting fatty acid synthesis in bacteria, PTM is thought to be a promising agent for overcoming antibiotic resistance.²PTM is also a selective inhibitor of the mammalian fatty acid synthase and has been shown to reduce liver triglyceride levels and to improve insulin sensitivity in a diabetic mouse model after an oral dose of 30 mg/kg.³

参考文献：

1. Wang, J., Soisson, S.M., Young, K., et al. Platensimycin is a selective FabF inhibitor with potent antibiotic properties. Nature 441(7091), 358-361 (2006).

2. Allahverdiyev, A.M., Bagirova, M., Abamor, E.S., et al. The use of platensimycin and platencin to fight antibiotic resistance. Infect. Drug Resist. 6, 99-114 (2013).

3. Wu, M., Singh, S.B., Wang, J., et al. Antidiabetic and antisteatotic effects of the selective fatty acid synthase (FAS) inhibitor platensimycin in mouse models of diabetes. Proc. Natl. Acad. Sci. USA 108(13), 5378-5383 (2011).