RWJ63556是一种可口服的COX-2selective/5-lipoxygenase抑制剂，具有抗炎活性。
CAS：190967-35-2
分子式：C11H10FNO3S2
分子量：287.33
纯度：98%
存储：Store at -20°C

Background:

RWJ 63556 is an orally active COX-2 selective/5-lipoxygenase inhibitor, with anti-inflammatory activities.

RWJ 63556 is a potent inhibitor of leukocyte influx over a period of 24 hr and maintains its in vitro profile on eicosanoids[1].

RWJ 63556 (1 mg/kg, i.v.) significantly inhibits the development of SP-induced oedema[2].

[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101. [2]. Le Filliatre G, et al. Cyclo-oxygenase and lipoxygenase pathways in mast cell dependent-neurogenic inflammation induced by electrical stimulation of the rat saphenous nerve. Br J Pharmacol. 2001 Apr;132(7):1581-9.