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AZD2014(Vistusertib)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
AZD2014(Vistusertib)图片
CAS NO:1009298-59-2
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
AZD-2014
产品介绍

生物活性

Vistusertib (AZD2014)是一种新型mTOR抑制剂,无细胞试验中IC50为2.8 nM;对多种PI3K亚型(α/β/γ/δ)具有较高选择性。浓度为1 μM时,对大多数激酶无或有微弱结合力。

靶点信息

mTOR (Cell-free assay)P-Akt (S473) (Cell-free assay)pS6 (S235/236) (Cell-free assay)
2.8 nM80 nM200 nM

化学数据

目录号A11303
作用机制Inhibitor (抑制剂)
M. Wt462.5
FormulaC25H30N6O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.1009298-59-2
SynonymsAZD-2014
SMILESC[C@H]1COCCN1C2=NC(=NC3=C2C=CC(=N3)C4=CC(=CC=C4)C(=O)NC)N5CCOC[C@@H]5C

溶解度

In vitro (25°C)DMSO32 mg/mL (69.18 mM)
WaterInsoluble
EthanolInsoluble
In vivo5% DMSO+30% PEG 300+ddH2O4 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.62 mL108.11 mL216.22 mL
0.5 mM4.32 mL21.62 mL43.24 mL
1 mM2.16 mL10.81 mL21.62 mL
5 mM0.43 mL2.16 mL4.32 mL

*The above data is based on the productmolecular weight 462.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.