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Physcion
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Physcion图片
CAS NO:521-61-9
包装:20mg
规格:98%
市场价:864元
分子量:284.27

产品介绍
Anthraquinone found in Rheum emodi
CAS:521-61-9
分子式:C16H12O5
分子量:284.27
纯度:98%
存储:Store at -20°C

Background:

Physcion (Parietin) is an anthraquinone isolated from traditional Chinese medicine Radix et Rhizoma Rhei, acts as an inhibitor of 6-phosphogluconate dehydrogenase, with an IC50 and a Kd of 38.5 μM and 26.0 μM, respectively[1][2]. Physcion (Parietin) exhibits laxative, hepatoprotective, anti-inflammatory, anti-microbial, anti-proliferative and anti-tumor effects[2].


参考文献:
[1]. Lin R, et al. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.
[2]. Pang MJ, et al. Physcion, a naturally occurring anthraquinone derivative, induces apoptosis and autophagy in human nasopharyngeal carcinoma. Acta Pharmacol Sin. 2016 Dec;37(12):1623-1640.