生物活性
PR-171 (Carfilzomib)是四肽环氧酮和选择性蛋白酶体抑制剂。它是环氧霉素的类似物。
靶点信息
| Proteasome (ANBL-6 cells) | | | | |
| 5 nM | | | | |
化学数据
| 目录号 | A11278 |
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 719.9 |
| Formula | C40H57N5O7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles. |
| CAS No. | 868540-17-4 |
| Synonyms | PR-171-007 |
| SMILES | CC(C)C[C@@H](C(=O)[C@]1(CO1)C)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC3=CC=CC=C3)NC(=O)CN4CCOCC4 |
溶解度
| In vitro (25°C) | DMSO | 46 mg/mL (63.89 mM) |
| Water | Insoluble |
| Ethanol | Insoluble |
| In vivo | 2% DMSO+30% PEG 300+2%Tween 80+ddH2O | 1 mg/mL |
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
储备液配制
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
| 0.1 mM | 13.89 mL | 69.45 mL | 138.91 mL |
| 0.5 mM | 2.78 mL | 13.89 mL | 27.78 mL |
| 1 mM | 1.39 mL | 6.95 mL | 13.89 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.78 mL |
*The above data is based on the productmolecular weight 719.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
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