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Cyproheptadine hydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Cyproheptadine hydrochloride图片
CAS NO:969-33-5
包装:50mg
规格:98%
市场价:643元
分子量:323.86

产品介绍
serotonin and histamine antagonist as well as antimuscarinic reagent
CAS:969-33-5
分子式:C21H22ClN
分子量:323.86
纯度:98%
存储:Store at -20°C

Background:

Cyproheptadine hydrochloride is an antagonist of serotonin receptor [1].


Cyproheptadine is a serotonin and histamine antagonist as well as an antimuscarinic reagent. It is used to treat for postgastrectomy-dumping syndrome, pruritic dermatoses, migraine, anorexia, and pituitary-dependent Cushing's syndrome. The major urinary product of cyproheptadine is cyproheptadine glucuronide, a quaternary ammonium compound. Cyproheptadine has some side effects including sedation, drowsiness, hypotension, tachycardia and blood dyscrasias. As a 5-HT2A receptor antagonist, cyproheptadine is found to reverse serotonin-enhanced ADP-induced platelet aggregation in vitro and ex vivo suggesting its antiplatelet and thromboprotective effects. [1, 2]


参考文献:
[1] Levine B, Green-Johnson D, Hogan S, Smialek JE.  A cyproheptadine fatality. J Anal Toxicol. 1998 Jan-Feb;22(1):72-4.
[2] Lin OA, Karim ZA, Vemana HP, Espinosa EV, Khasawneh FT.  The antidepressant 5-HT2A receptor antagonists pizotifen and cyproheptadine inhibit serotonin-enhanced platelet function. PLoS One. 2014 Jan 23;9(1):e87026.