Eletriptan is an agonist of the serotonin (5-HT) receptor types 5-HT1B and 5-HT1D.
CAS：143322-58-1
分子式：C22H26N2O2S
分子量：382.5
纯度：98%
存储：Store at -20°C

Background:

Eletriptan is an agonist of the serotonin (5-HT) receptor types 5-HT1B and 5-HT1D. It inhibits forskolin-induced cAMP accumulation in and induces vasoconstriction of isolated rabbit common carotid artery rings (pD2s = 7.6 and 4.9, respectively), an effect that can be blocked by the 5-HT1B antagonist SB216641 but not the 5-HT1D antagonist BRL15572. Eletriptan preferentially induces constriction of isolated human cerebral over coronary arteries (EC50s = 15.8 and 1,995 nM, respectively). Formulations containing eletriptan have been used in the treatment of migraine headache.