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LY-411575
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
LY-411575图片
CAS NO:209984-57-6
包装与价格:
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议
10mM * 1mL in DMSO电议

产品名称
LY411575
产品介绍

生物活性

LY-411575是一种选择性的,细胞可渗透的小分子γ-secretase抑制剂。在表达APP或NΔE的HEK293细胞中IC50为0.078 nM/0.082 nM(基于膜/细胞),也抑制Notch分裂,IC50为0.39 nM。

靶点信息

γ secretase (membrane-based) (HEK293 cells expressing either APP or NδE)γ secretase (cell-based) (HEK293 cells expressing either APP or NδE)Notch S3 cleavage (HEK293 cells expressing either APP or NδE)
0.078 nM0.082 nM0.39 nM

化学数据

目录号A11176
作用机制Inhibitor (抑制剂)
M. Wt479.48
FormulaC26H23F2N3O4
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.209984-57-6
SynonymsLY411575
SMILESC[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)[C@H](C4=CC(=CC(=C4)F)F)O

溶解度

In vitro (25°C)DMSO94 mg/mL (196.04 mM)
WaterInsoluble
Ethanol13 mg/mL (27.11 mM)
In vivo30% PEG400+0.5% Tween80+5% propylene glycol28 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM20.86 mL104.28 mL208.56 mL
0.5 mM4.17 mL20.86 mL41.71 mL
1 mM2.09 mL10.43 mL20.86 mL
5 mM0.42 mL2.09 mL4.17 mL

*The above data is based on the productmolecular weight 479.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.