您好,欢迎来到试剂仪器网! [登录] [免费注册]
试剂仪器网
位置:首页 > 产品库 > YO-01027
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
YO-01027
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
YO-01027图片
CAS NO:209984-56-5
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
10mM * 1mL in DMSO电议

产品名称
YO01027, Dibenzazepine, Deshydroxy LY 411575
产品介绍

生物活性

YO-01027是一种二肽γ-secretase抑制剂,作用于APPL和Notch分裂, 无细胞试验中IC50分别为2.6 nM和2.9 nM,一种抗阿尔茨海默氏病药物。

靶点信息

γ secretase(APPL) (Cell-free assay)γ secretase(Notch) (Cell-free assay)
2.6 nM2.9 nM

化学数据

目录号A11174
作用机制Inhibitor (抑制剂)
M. Wt463.48
FormulaC26H23F2N3O3
Purity>99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for36 months.
In solution, store at -20ºC and use within3 monthsto prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No.209984-56-5
SynonymsYO01027, Dibenzazepine, Deshydroxy LY 411575
SMILESC[C@@H](C(=O)N[C@H]1C2=CC=CC=C2C3=CC=CC=C3N(C1=O)C)NC(=O)CC4=CC(=CC(=C4)F)F

溶解度

In vitro (25°C)DMSO87 mg/mL (187.7 mM)
WaterInsoluble
EthanolInsoluble
In vivo0.5% hydroxyethyl cellulose5 mg/mL
*<1 mg/ml means slightly soluble or insoluble.
*Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

储备液配制

Concentration / Solvent Volume / Mass1 mg5 mg10 mg
0.1 mM21.58 mL107.88 mL215.76 mL
0.5 mM4.32 mL21.58 mL43.15 mL
1 mM2.16 mL10.79 mL21.58 mL
5 mM0.43 mL2.16 mL4.32 mL

*The above data is based on the productmolecular weight 463.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.